EDITORIAL SECTION

Articles

Spleen Cytokines Against Inflammatory Bowel Disease

Over one hundred years ago at the University of Toronto Frederick Banting Charles Best and James Collip extracted protein insulin from the pancreas that saved the lives of millions of diabetics since then It is possible that the proteins extracted from the spleen can also help people with inflammatory bowel disease IBD

Access to Affordable Medicines: A Persistent Challenge for Europe

The problem of affordable medicines has been topical in Europe for many years Despite the fact that there are well developed health units in many regions of the world and particularly in this continent the health challenges of the population have not been fully met especially in access to affordable basic medicines This problem is relevant not only to the patients but also to the stability of heal...

Adapting to the Changing Landscape of Clinical Trials in Europe

Clinical trials constitute the backbone of medical research driving innovation and shaping the landscape of healthcare Over the years Europe has experienced a profound transformation in its approach to clinical trials

Global CDMO Expansion: Supporting the Growing Advanced Therapy Pipeline

The European advanced therapy sector has spent the better part of two decades proving a scientific point that engineered cells corrected genes and reprogrammed immune systems can deliver durable clinical benefit That argument is now largely settled The question facing pharmaceutical and biotech leadership is industrial rather than scientific whether these therapies can be manufactured consistentl...

Artificial Intelligence and Deep/Machine Learning(AI & D/ML) or Artificial Neural Network (ANN): Implications for pharmaceutical product development processes

Producing pharmaceutical products without untoward effects but with desired qualities is not only the very basic requirement set by regulatory authorities but also indirectly decides the success of the pharma industry The pharmaceutical product development process is a combined and coordinated work from numerous divisions of the pharma industry which usually starts

Mini-Tablets: A Valid Strategy to Combine Efficacy and Safety in Pediatrics

People respond very differently to medications depending on their weight age inborn capability to metabolize drugs the individual characteristics of the disease or the presence of comorbidities The wellknown assumption that one size fits all has clearly revealed all its limitations and become questionable Notably among humans pediatric patients represent

Techno Trends

University of Dundee’s Cabamiquine Shows Promise for Single-Dose Malaria Treatment

Researchers at the University of Dundee have reported encouraging clinical results for cabamiquine a novel antimalarial compound being developed as a potential singledose treatment for malaria

Projects

Genentech to Invest US$750 Million in Oregon Device Fill-Finish Facility

Genentech a member of the Roche Group plans to invest approximately US million in a new device fillfinish manufacturing facility at its acre campus in Hillsboro Oregon The project will add endtoend manufacturing

Research Insights

Induction of osteogenic differentiation of MSCs by GSK3β knockdown through GSK3β siRNAs transfection

The development of effective strategies for treating bone defects can be based on gene therapy methods aimed at regulating the differentiation of osteoprogenitor cells One of the approaches is to use siRNA mo

whitepaper

Post-Translational Modifications in Drug Discovery: From Molecular Regulation to Clinical Impact

For decades the central dogma of molecular biology has anchored our understanding of cellular function DNA to RNA to protein But this linear view is incomplete A growing body of evidence shows that much of biologys