EDITORIAL SECTION

Articles

Advanced Robotics and Autonomous Operations in Pharma Production

Walk the production floor of almost any modern European pharmaceutical site and you will find robots already at work Sixaxis arms denest syringe tubs Gantries load and unload lyophilisers Autonomous mobile units ferry pallets between the warehouse and the dispensary Robotics arrived in pharmaceutical manufacturing more than two decades ago and in the purely mechanical sense the argument was won lo...

Renewable Energy Solutions for Pharma Factories: Powering Sustainable Pharmaceutical Manufacturing

One of the most energyconsuming sectors of the industrial sector is the pharmaceutical manufacturing Energy requirement in the pharma factories is continuous and critical whether it is controlled environments and cleanrooms continuous production lines HVAC system cold storage as well as quality testing laboratories With the increasing regulatory pressure ESG undertakings and the cost of energy ren...

Cybersecurity in Pharma: The Threat No One Budgeted For

There is a particular kind of risk that organisations are bad at pricing the one that has never happened to them Pharmaceutical companies have spent a generation building sophisticated defences against the risks they know intimatelycontamination adulteration deviation recall Quality systems are mature inspectionready and deeply funded Cyber risk has never enjoyed that status It sat in the IT budge...

Adapting to the Changing Landscape of Clinical Trials in Europe

Clinical trials constitute the backbone of medical research driving innovation and shaping the landscape of healthcare Over the years Europe has experienced a profound transformation in its approach to clinical trials

The Role of Biopharmaceutics in Early Drug Development

Biopharmaceutics is a major branch in pharmaceutical lores which relates between the physicochemical parcels of a medicine in lozenge form and the pharmacology toxicology or clinical response observed after its administration medicineefficacity and safety are dependent on the dosing authority The optimal lozenge and dosing intervals can be relatively different for different medicines Also for a si...

Digital Biomarkers and Wearables: Transforming Clinical Trial Data Collection

A participant enrolled in a week pharmaceutical trial may spend fewer than six hours inside a clinical site The remaining odd hours of that year the stairs the fatigue the broken nights the good days and the collapsed ones pass unrecorded Clinical development has quietly accepted this trade for decades building enormous capital decisions on a handful of supervised snapshots taken under artificia...

Techno Trends

Alume Biosciences Secures FDA Breakthrough Therapy Designation for Bevonescein

Alume Biosciences has received Breakthrough Therapy Designation BTD from the US Food and Drug Administration FDA for bevonescein an investigational fluorescent drug being developed to support realtime nerve visualisation during head and neck surgery in adults Bevonescein is an intravenous fluorescent peptidedye conjugate that binds to nerve tissue

Projects

SK pharmteco Plans More Than US$200 Million Investment in Small Molecule and Peptide Manufacturing

SK pharmteco is planning a fiveyear investment of more than US million to expand and modernise its pharmaceutical development and manufacturing operations in the United States The programme will strengthen capabilities for small molecules and peptides while supporting a more

Research Insights

A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG

PIGACDG is a congenital disorder of glycosylation caused by pathogenic partial lossoffunction variants in the PIGA gene PIGA encodes an enzyme responsible for the catalytic transfer of Nacetylglucosamine

whitepaper

Post-Translational Modifications in Drug Discovery: From Molecular Regulation to Clinical Impact

For decades the central dogma of molecular biology has anchored our understanding of cellular function DNA to RNA to protein But this linear view is incomplete A growing body of evidence shows that much of biologys