EDITORIAL SECTION

Articles

Data Security Challenges in Pharma IT: Safeguarding Sensitive Information

The pharmaceutical industry faces several data security challenges in its IT infrastructure primarily related to safeguarding sensitive information The nature of the data regulatory requirements and the increasing sophistication of cyber threats

Strategic Partnerships and Collaborations in the European Pharmaceutical Industry

Pharma strategic partnerships are formal agreements in which two or more companies share resources risk and rewards to develop or commercialize medicines In Europe the main models are licensing codevelopment cocommercialization joint ventures and publicprivate consortia Companies choose based on how much risk they want to share how much control they need to keep

What Is Clinical Pharmacology and Its Importance for Drug Development and Patient Care

Clinical pharmacology is the critical interface between laboratory science and the education of patients Put simply it is the science that researches the interaction of drugs with the human body and the reaction of the latter to drugs People pose the question what is clinical pharmacology The solution can be found in its multidisciplinary character of the matter combining pharmacology medicine ge...

Why is Pharmacogenetics and Pharmacogenomics Important?

In a world of increasingly personalized medicine the fields of pharmacogenetics and pharmacogenomics are gaining importance These disciplines explore the relationship between an individuals genetic makeup

Harnessing the Intracellular Machinery to Degrade Cellular Proteins

A countless number of proteins including growth factors receptors and cytokines play a pivotal role during the onset and exacerbation of numerous human diseases including cancer autoimmune and inflammatory disorders Of these proteins extracellular and membraneassociated proteins represent around of human proteome

Pharmaceutical Business Strategy: Transformation, Regulation, Outsourcing and Growth

The pharmaceutical industry is standing at an unusual crossroads Patent cliffs are steeper regulators are tougher patients expect more transparency and payers are pushing back harder on price In this environment a strong Pharma Business Strategy is no longer a slide deck exercise for the boardroom its the difference between a company that scales globally and one that quietly fades into irrelevanc...

Techno Trends

Alume Biosciences Secures FDA Breakthrough Therapy Designation for Bevonescein

Alume Biosciences has received Breakthrough Therapy Designation BTD from the US Food and Drug Administration FDA for bevonescein an investigational fluorescent drug being developed to support realtime nerve visualisation during head and neck surgery in adults Bevonescein is an intravenous fluorescent peptidedye conjugate that binds to nerve tissue

Projects

SK pharmteco Plans More Than US$200 Million Investment in Small Molecule and Peptide Manufacturing

SK pharmteco is planning a fiveyear investment of more than US million to expand and modernise its pharmaceutical development and manufacturing operations in the United States The programme will strengthen capabilities for small molecules and peptides while supporting a more

Research Insights

A drug repurposing screen reveals dopamine signaling as a candidate therapeutic pathway for PIGA-CDG

PIGACDG is a congenital disorder of glycosylation caused by pathogenic partial lossoffunction variants in the PIGA gene PIGA encodes an enzyme responsible for the catalytic transfer of Nacetylglucosamine

whitepaper

Post-Translational Modifications in Drug Discovery: From Molecular Regulation to Clinical Impact

For decades the central dogma of molecular biology has anchored our understanding of cellular function DNA to RNA to protein But this linear view is incomplete A growing body of evidence shows that much of biologys